Pediatric and Adolescent Endocrinology

MTP19 - Management of 46, XY DSD Across the Lifespan: A Multidisciplinary Team Perspective

Sunday, June 14, 2026

2:35 PM - 3:15 PM CT

Location: Room W375C

Meet the Professor Speaker(s)

Berenice Bilharinho Mendonca, MD, PhD (she/her/hers)

Senior Professor
University Sao Paulo Fac Medical
Sao Paulo, Sao Paulo, Brazil

Disclosure(s):

Berenice Mendonca, MD: No financial relationships to disclose

Explain the biological basis of typical and atypical sexual development.
Outline a systematic, empathetic approach to the prenatal diagnosis and neonatal assessment of a child with atypical genitalia.
Describe the step-by-step diagnostic evaluation for a difference of sex development (DSD) based on karyotype.
Discuss the complex, shared decision-making process for sex of rearing assignment within a multidisciplinary team.
Formulate a management plan for the first years of life, including medical treatment, timing of surgery, and psychosocial support.
Differentiate among common DSD etiologies (eg, congenital adrenal hyperplasia [CAH], complete androgen insensitivity syndrome [CAIS], 5α-reductase deficiency, gonadal dysgenesis) using clinical cases spanning prenatal to adolescent presentations.