MON-132 - Impact of Dyslipidemia on the Probability of Pregnancy in Women Undergoing IVF: A Systematic Review and Meta-Analysis

Background/

Aims: Dyslipidemia, including high concentrations of total cholesterol (TC) or low-density lipoprotein cholesterol (LDL-C) or triglycerides (TG), as well as low levels of high-density lipoprotein cholesterol (HDL-C), adversely affect cardiovascular health. However, its specific impact on in vitro fertilization (IVF) is unknown. The purpose of this study was to systematically review and meta-analyze the best available evidence regarding the impact of dyslipidaemia on IVF outcomes. The primary outcome was live birth rates, while secondary outcomes included clinical pregnancy rates, cumulative live birth and miscarriage rates.

Methods: A comprehensive literature search in PubMed, Scopus and Google Scholar was conducted until 10 January 2026. Data from eligible studies were independently extracted by two reviewers, including demographic, methodological and clinical information. Study quality was assessed using the Newcastle-Ottawa Scale. Statistical heterogeneity was evaluated using the I² statistic, and meta-analyses were conducted using random- or fixed-effects models, depending on the presence of significant heterogeneity. Results were expressed as relative risks (RR) or weighted mean differences (WMD) with 95% confidence intervals (CIs) and were analysed using an intention-to-treat principle.

Results: Six retrospective studies (n=11,685) published between 2018 and 2024 with moderate-to-low risk of bias were analysed. Sample size ranged from 127 to 3,372 patients. Clinical pregnancy rates were lower in patients with dyslipidemia compared to those without (RR 0.85, 95% CI 0.74–0.99; random effects model; I² 73.4%; five studies, 5,477 patients). Dyslipidemia was associated with higher miscarriage rate (RR 1.24, 95% CI 1.01–1.53; I²: 0%; four studies, 5,019 patients) compared with normal lipid profile. Furthermore, patients with dyslipidemia had lower live birth rates compared to those without (RR 0.82, 95% CI 0.68–0.99; I² 89.4%; three studies, 4,972 patients).

Conclusions: This systematic review and meta-analysis is the first performed so far on this topic, showing decreased pregnancy outcomes in women with dyslipidaemia compared to those without. This underscores the importance of lipid profile screening before infertility treatment and necessitates prompt lifestyle intervention to reduce this effect.

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