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Hisham Mohammed, PhD

Associate Professor
OREGON HEALTH SCIENCES UNIVERSITY
Tigard, OR, United States

Hisham Mohammed, PhD, is an Associate Professor and Assistant Director of the Quantitative Oncology Program at the Knight Cancer Institute, Oregon Health & Science University. His laboratory investigates how transcription factors and their associated chromatin regulatory complexes establish differentiation-state plasticity, drive transcriptional heterogeneity, and underlie therapeutic resistance in hormone-driven cancers. Dr. Mohammed invented RIME (Rapid Immunoprecipitation Mass Spectrometry of Endogenous Proteins), a widely adopted proteomic method for interrogating endogenous transcription factor complexes, which his group used to uncover how the progesterone receptor directly reprograms estrogen receptor chromatin binding in breast cancer, work that has helped motivate multiple clinical trials evaluating progesterone as a therapeutic agent. His current research applies single-cell and spatial multi-omic approaches to define the transcriptional and epigenetic cell states that accompany the transition from primary to metastatic ER+ breast cancer and the evolution of estrogen receptor function over disease progression. Dr. Mohammed completed his PhD in Oncology at the University of Cambridge and is a recipient of the Endocrine Society Early Investigator Award.

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