SY43 - Steroid Receptor Actions in Immunity

Symposium Chair(s)

• 

  Morag Young, PhD (she/her/hers)

  Heart Failure Program coLead
  Baker Heart and Diabetes Institute
  Melbourne, Australia

  Disclosure(s): No financial relationships to disclose
• PI

  Priya Issuree, PhD

  University of Iowa, Carver College of Medicine MSEP Program
  Iowa City, IA, United States

  Disclosure information not submitted.

Steroid hormone receptors are powerful regulators of immune cell identity and function, with important implications for cardiometabolic and inflammatory disease. This session will examine how glucocorticoid and estrogen receptor signaling shape macrophage and monocyte biology at molecular, cellular, and functional levels. Topics will include epigenomic mechanisms underlying macrophage programming by glucocorticoids and cytokine signaling, estrogen receptor-mediated regulation of monocyte and macrophage function, and emerging links between estrogen signaling, PARP1, and immune cell responses during metabolic stress. By integrating insights from immunology, epigenomics, endocrinology, and cardiovascular research, this session will highlight how steroid receptor actions in immune cells contribute to disease pathogenesis and may uncover novel immune-targeted therapeutic strategies.

Presentations:

• 10:30 AM - 11:00 AM CT

  At the Crossroads of Signaling: PARP1 as a Tissue-Specific Mediator of Inflammatory and Hormonal Programs
  

  Symposium Speaker: Dan Huang, MD, PhD (she/her/hers) – University of Texas Southwestern Medical Center
• 11:00 AM - 11:30 AM CT

  Differential Epigenomic and Transcriptional Programming of Macrophage Functional States
  

  Symposium Speaker: Inez Rogatsky, PhD (she/her/hers) – Hospital for Special Surgery
• 11:30 AM - 12:00 PM CT

  Androgens Modulate the Immune Profile in a Mouse Model of Polycystic Ovary Syndrome
  

  Symposium Speaker: Sara Torstensson, PhD (she/her/hers) – KAROLINSKA INSTITUTET