SY68 - When Good Complexes Go Bad: Dissecting the Nuclear Receptor Complexes that Drive Disease

Symposium Chair(s)

• 

  David Moore, PhD (he/him/his)

  Prof
  UNIVERSITY OF CALIFORNIA - BERKELEY
  Berkley, CA, United States

  Disclosure(s): No financial relationships to disclose
• 

  Julie Ostrander, PhD (she/her/hers)

  Associate Professor
  Masonic Cancer Center
  University of Minnesota
  Minneapolis, MN, United States

  Disclosure(s): No financial relationships to disclose

Nuclear receptors form functional complexes to affect transcriptional activities. While these complexes may be part of its normal protein functions, their dysfunctions can drive disease pathologies. New technologies offer promise to

identify how interacting proteins change to impact both disease and healthy states. Defining and dissecting the roles of such functional nuclear receptor complexes will improve our understanding of endocrine actions while revealing

new opportunities for therapeutic intervention.

Presentations:

• 10:45 AM - 11:15 AM CT

  Usurping AR Complexes to Drive Therapy Resistance in Prostate Cancer
  

  Symposium Speaker: Steven Kregel, PhD, MS (he/him/his) – Loyola University Chicago
• 11:15 AM - 11:45 AM CT

  Evolution of Estrogen Receptor Function Across Breast Cancer Progression: A Single-Cell and Spatial View
  

  Symposium Speaker: Hisham Mohammed, PhD – OREGON HEALTH SCIENCES UNIVERSITY
• 11:45 AM - 12:15 PM CT

  A New FADS Pathway to Endocrine Resistance in Breast Cancer
  

  Symposium Speaker: Carol Sartorius, PhD – University of Colorado Anschutz Medical Center