SY10 - Hormone Havoc: The Ups and Downs of PTH/PTHrP Signaling

Saturday, June 13, 2026

10:45 AM - 12:15 PM CT

Location: Room W181AB

Symposium Chair(s)

JP

J Carl Pallais, MD,MPH

Doctor
Brigham and Women's Hospital
Cambridge, MA, United States

Disclosure information not submitted.

Disclosure(s):

Murat Bastepe, MD,PhD: No relevant disclosure to display

Giovanna Mantovani, MD, PhD: No financial relationships to disclose

Lee S. Weinstein, MD: No financial relationships to disclose

The spectrum of pseudohypoparathyroidism (PHP) continues to expand with advances in our understanding of its genetic and physiological mechanisms. This has enabled more precise classifications of PHP and related disorders, such as acrodysostosis, and clarified both their unique features and overlapping characteristics. Insights into PTH/PTHrP and GNAS signaling pathways have revealed their central roles in diverse biological processes. Beyond calcium and phosphate homeostasis, dysregulation of these pathways contributes to ectopic ossification and impacts energy balance and obesity-topics that will be highlighted and discussed in this symposium.

Presentations:

10:45 AM - 11:15 AM CT

Pseudohypoparathyroidism and Acrodysostosis: New Perspectives on the Biology and Classification
Symposium Speaker: Murat Bastepe, MD,PhD (he/him/his) – MASSACHUSETTS GENERAL HOSPITAL
11:15 AM - 11:45 AM CT

Crystals in the Wrong Place: Ectopic Ossification in Inactivating PTH/PTHrp/GNAS Disorders
Symposium Speaker: Giovanna Mantovani, MD, PhD (she/her/hers) – University of Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
11:45 AM - 12:15 PM CT

The Many Faces of G Protein Signaling in Obesity
Symposium Speaker: Lee S. Weinstein, MD (he/him/his) – NIDDK/NIH