ORF32 - New Therapies and Perspectives for Congenital Adrenal Hyperplasia and Adrenal Insufficiency

ORF Chair-Primary(s)

• 

  Lauren Fishbein, MD, PhD

  University of Colorado School of Medicine
  Aurora, CO, United States

  Disclosure information not submitted.

Presentations:

• 1:45 PM - 1:50 PM CT

  Model-Informed Atumelnant Dose Selection for a Phase 3 Study in Adult Patients with Classic Congenital Adrenal Hyperplasia
  

  Rapid and Poster Presenter: Laura Curd, MS (she/her/hers) – Crinetics Pharmaceuticals, Inc.

  Co-Author: Xiaoli Wang, PhD – Crinetics Pharmaceuticals

  Co-Author: Adam Worob, PhD – A2-Ai

  Co-Author: Davide Romeres, PhD – A2-Ai

  Co-Author: Ryan L. Crass, PharmD – A2-Ai

  Co-Author: Alejandro Ayala, MD – Crinetics Pharmaceuticals

  Co-Author: Carl LaCerte, MS – Crinetics Pharmaceuticals
• 1:50 PM - 1:55 PM CT

  Long-Term Risk of Cardiometabolic Comorbidities Associated with Glucocorticoid Exposure and Androgen Control in Classic Congenital Adrenal Hyperplasia: A Cox Proportional Hazards Analysis from the CAHtalog™ Registry
  

  Rapid and Poster Presenter: Oksana Lekarev, DO (she/her/hers) – Weill Cornell Medicine

  Co-Author: Deepa Jahagirdar, PhD – Cytel

  Co-Author: Chelsea McKibbon, MS – Cytel

  Co-Author: Karen L. Su, MD – Weill Cornell Medicine

  Co-Author: Dina Matos, BA – CARES Foundation

  Co-Author: Vivian H. Lin, MD – Neurocrine Biosciences, Inc.

  Co-Author: Sanjay Keswani, MD – Neurocrine Biosciences, Inc.

  Co-Author: George S. Jeha, MD – Neurocrine Biosciences, Inc.

  Co-Author: Ginny P. Sen, MPH – NEUROCRINE BIOSCIENCES

  Co-Author: Ginny P. Sen, MPH – NEUROCRINE BIOSCIENCES
• 1:55 PM - 2:10 PM CT

  Cardiometabolic and Patient-Reported Outcomes of Low-Dose Once-Daily Prednisolone Versus Standard Divided-Dose Hydrocortisone in Adrenal Insufficiency: A Multicentre Crossover Study (HYPER-AID Study)
  

  Oral Abstract Presenter: Zin Htut, MBBS, MRCP(UK) (she/her/hers) – IMPERIAL COLLEGE LONDON

  Co-Author: Katharine Lazarus, n/a – IMPERIAL COLLEGE SCHOOL OF MEDICINE

  Co-Author: Kavita Narula, n/a – Imperial College Healthcare NHS Trust

  Co-Author: Cara Go, n/a – Imperial College Healthcare NHS Trust

  Co-Author: Aastha Mundhra, n/a – Imperial College London

  Co-Author: Angelica Sharma, n/a – Imperial College Healthcare NHS Trust

  Co-Author: Sirazum Choudhury, n/a – IMPERIAL COLLEGE LONDON

  Senior Author/Primary Investigator: Karim Meeran, n/a – Imperial College London
• 2:10 PM - 2:25 PM CT

  Once Daily Atumelnant (CRN04894) Enables Lowering of Glucocorticoid Doses with Sustained Androgen Reduction in Adults with Congenital Adrenal Hyperplasia
  

  Oral Abstract Presenter: Umasuthan Srirangalingam, FRCP, PhD – University College London Hospitals

  Co-Author: Dario Bruera, MD – Hospital Misericordia

  Co-Author: Adriane Maria Rodrigues, MD, PhD – Universidade Federal do Paraná

  Co-Author: Alejandro Ayala, MD – Crinetics Pharmaceuticals

  Co-Author: Yang Wu, PhD – Crinetics Pharmaceuticals

  Co-Author: Eduardo De la Torre Ames, MD – Crinetics Pharmaceuticals

  Co-Author: Alan Krasner, MD (he/him/his) – Crinetics Pharmaceuticals, Inc.

  Co-Author: Peter J. Trainer, MD – Crinetics Pharmaceuticals

  Co-Author: Monica R. Gadelha, MD, PhD – Centro de Pesquisa Clínica, Instituto Estadual do Cérebro Paulo Niemeyer

  Co-Author: Nicole Reisch, MD, PhD – Medizinische Klinik and Poliklinik IV, Klinikum der Universität München, LMU München

  Co-Author: Flavia Amanda Costa-Barbosa, MD, PhD – Adrenal and Hypertension Unit, Division of Endocrinology and Metabolism, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo

  Co-Author: Vania dos Santos Nunes-Nogueira, MD, PhD – Department of Internal Medicine, São Paulo State University (UNESP), Medical School

  Co-Author: Richard J. Auchus, MD, PhD – University of Michigan

  Co-Author: Tania A.S.S. Bachega, MD, PhD (she/her/hers) – Laboratorio de Hormonios e Genetica Molecular-LIM 42, da Faculdade de Medicina da Universidade de São Paulo
• 2:25 PM - 2:40 PM CT

  Characterization of Children and Adolescents with Classic CAH WHO Had Slowed Bone Age Progression and Improved Height Prediction with Crinecerfont
  

  Oral Abstract Presenter: Maria G. Vogiatzi, MD – Children's Hospital of Philadelphia

  Co-Author: Martine Cools, MD, PhD – Ghent University Hospital and Ghent University

  Co-Author: Régis Coutant, MD, MS – CHU d’Angers

  Co-Author: Ayca Erkin-Cakmak, MD, MPH – University of California San Francisco and Benioff Children’s Hospital

  Co-Author: Oksana Lekarev, DO (she/her/hers) – Weill Cornell Medicine

  Co-Author: Laetitia Martinerie, MD, PhD – Robert Debré Hospital, APHP, Paris Cité University, and Inserm, Physiologie et Physiopathologie Endocriniennes

  Co-Author: Ron S. Newfield, MD – Rady Children's Hospital and University of California San Diego

  Co-Author: Kyriakie Sarafoglou, MD – University of Minnesota Medical School

  Co-Author: Jean L. Chan, MD – Neurocrine Biosciences, Inc.

  Co-Author: George S. Jeha, MD – Neurocrine Biosciences, Inc.

  Co-Author: Sanjay Keswani, MD – Neurocrine Biosciences, Inc.

  Co-Author: Rachel Manahan, PhD – Neurocrine Biosciences, Inc.

  Co-Author: Eiry Roberts, MD – Neurocrine Biosciences, Inc.

  Co-Author: Julia Sturgeon, MS – Neurocrine Biosciences, Inc.

  Co-Author: Mimi S. Kim, MD, MSc – Center for Endocrinology, Diabetes, and Metabolism, Children’s Hospital Los Angeles, University of Southern California
• 2:40 PM - 2:55 PM CT

  Analysis of the Glucocorticoid Treatment in Relation to Growth Outcomes in a Cohort of 1500 Children with Congenital Adrenal Hyperplasia - Real-World Data from the I-CAH Registry
  

  Oral Abstract Presenter: IRINA-ALEXANDRA BACILA, CLINICAL RESEARCH FELLOW IN PAEDIATRICS – THE UNIVERSITY OF SHEFFIELD

  Co-Author: Neil Lawrence, MBChB – The University of Sheffield

  Co-Author: Chamila Balagamage, MD – Birmingham Women's & Children's Hospital

  Senior Author/Primary Investigator: S Faisal Ahmed, MBChB,MD,FRCPCH (he/him/his) – Royal Hospital for Children

  Senior Author/Primary Investigator: Nils P. Krone, MD FRCPCH – University of Sheffield
• 2:55 PM - 3:10 PM CT

  Crinecerfont Improves Weight-Related Outcomes and Insulin Resistance in Adults with Classic Congenital Adrenal Hyperplasia: 2-Year Results from the CAHtalyst™ Adult Study
  

  Oral Abstract Presenter: Oksana Hamidi, DO – UT Southwestern Medical Center

  Co-Author: Laura J. Chalmers, MD – University of Oklahoma School of Community Medicine and Schusterman Center Clinic

  Co-Author: Henrik Falhammar, MD, PhD, FRACP, Associate Professor – Karolinska Institutet

  Co-Author: Andrea M. Isidori, MD, PhD – Sapienza University of Rome

  Co-Author: Patrice Rodien, MD, PhD – CHU d’Angers and Labatoire MITOVASC, Université d’Angers

  Co-Author: Maamoun Salam, MD – Washington University School of Medicine

  Co-Author: Umasuthan Srirangalingam, FRCP, PhD – University College London Hospitals

  Co-Author: Jean L. Chan, MD – Neurocrine Biosciences, Inc.

  Co-Author: Andrea L. Hartzell, PhD – Neurocrine Biosciences, Inc.

  Co-Author: Sanjay Keswani, MD – Neurocrine Biosciences, Inc.

  Co-Author: Vivian H. Lin, MD – Neurocrine Biosciences, Inc.

  Co-Author: Eiry Roberts, MD – Neurocrine Biosciences, Inc.

  Co-Author: Julia Sturgeon, MS – Neurocrine Biosciences, Inc.

  Co-Author: Deborah P. Merke, MS, MD – NIH