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Topic: Adipose Tissue_Appetite_and Obesity
Session Type: Oral Abstract/Rapid-Fire

ORF50 - Adipose Tissue, Appetite, and Obesity: Emerging and Established Pharmacotherapies

Monday, June 15, 2026
1:45 PM - 3:15 PM CT
Location: Room W185ABC

    ORF Chair-Primary(s)

  • FO

    Fernando Ovalle, MD

    Professor of Medicine & Division Director
    University of Alabama at Birmingham
    Birmingham, AL, United States

    Disclosure information not submitted.

  • Elif Oral, MD (she/her/hers)

    Professor
    MEND, Internal Medicine
    University of Michigan
    Ann Arbor, MI, United States

    Disclosure(s): • Chiesi Global Rare Diseases: Advisory Board (), Clinical Trial Investigator (), Consultant (), Contracted Research (Principal Investigators must provide information, even if received by the institution) (), Grant Recipient (), Honorarium Recipient (), intellectual property from Myalept (royalty fees), clerical writing supportl (); Ionis: Clinical Trial Investigator (), Contracted Research (Principal Investigators must provide information, even if received by the institution) (), Manuscript support (); Morphic Medical: Clinical Trial Investigator (); Regeneron: Advisory Board (), Clinical Trial Investigator (), Contracted Research (Principal Investigators must provide information, even if received by the institution) (), Grant Recipient (); Rejuvenate Bio: Advisory Board (); Rhythm: Clinical Trial Investigator ()

Disclosure(s):
Elif A. Oral, MD: • Chiesi Global Rare Diseases: Advisory Board (), Clinical Trial Investigator (), Consultant (), Contracted Research (Principal Investigators must provide information, even if received by the institution) (), Grant Recipient (), Honorarium Recipient (), intellectual property from Myalept (royalty fees), clerical writing supportl (); Ionis: Clinical Trial Investigator (), Contracted Research (Principal Investigators must provide information, even if received by the institution) (), Manuscript support (); Morphic Medical: Clinical Trial Investigator (); Regeneron: Advisory Board (), Clinical Trial Investigator (), Contracted Research (Principal Investigators must provide information, even if received by the institution) (), Grant Recipient (); Rejuvenate Bio: Advisory Board (); Rhythm: Clinical Trial Investigator ()

Presentations:

  • 1:45 PM - 1:50 PM CT
    Biased Signaling of Melanocortin 4 Receptor and Associations with Increased or Reduced Body Weight

    Submitting author: Lisa Ruck – Charite Universitaetsmedizin Berlin

    Rapid and Poster Presenter: Lisa Ruck – Charite Universitaetsmedizin Berlin

    Co-Author: Sarah Zschunke, n/a – Charite Universitaetsmedizin Berlin

    Co-Author: Philipp Gmach, n/a – Charite Universitaetsmedizin Berlin

    Co-Author: Sabine Jyrch, n/a – Charite Universitaetsmedizin Berlin

    Co-Author: Susanna Wiegand, n/a – Charite Universitaetsmedizin Berlin

    Co-Author: Gunnar Kleinau, n/a – Charite Universitaetsmedizin Berlin

    Co-Author: Monique Gallandi, n/a – Charite Universitaetsmedizin Berlin

    Co-Author: Louisa Calabrese, n/a – Charite Universitaetsmedizin Berlin

    Co-Author: Nicolas Heyder, n/a – Charite Universitaetsmedizin Berlin

    Co-Author: Manuel Troll, n/a – Universitaetsklinikum Leipzig

    Co-Author: Annette Beck-sickinger, n/a – Universitaetsklinikum Leipzig

    Co-Author: Heike Biebermann, n/a – Charite Universitaetsmedizin Berlin

    Co-Author: Patrick Scheerer, n/a – Charite Universitaetsmedizin Berlin

    Senior Author/Primary Investigator: Peter Kühnen, n/a – Charite Universitaetsmedizin Berlin

  • 1:50 PM - 1:55 PM CT
    Effects of Topiramate Plus Health Behavior and Lifestyle Treatment on Body Mass Index, Eating Behaviors, and Cognitive Outcomes Among 65 Adolescents with Severe Obesity

    Submitting author: Eric M. Bomberg, MD, MAS (he/him/his) – University of Minnesota Medical School

    Rapid and Poster Presenter: Eric M. Bomberg, MD, MAS (he/him/his) – University of Minnesota Medical School

    Senior Author/Primary Investigator: Eric M. Bomberg, MD, MAS (he/him/his) – University of Minnesota Medical School

    Co-Author: Jamie Forschmiedt, BS – University of Minnesota

    Co-Author: Kyle D. Rudser, PhD – University of Minnesota

    Co-Author: Aaron S. Kelly

    Senior Author/Primary Investigator: Amy C. Gross, PhD, LP, BCBA – University of Minnesota Medical School

    Co-Author: Amy C. Gross, PhD, LP, BCBA – University of Minnesota Medical School

  • 1:55 PM - 2:00 PM CT
    A BRINP3-Derived Peptide Drives Non-Aversive Appetite Suppression via PVH Circuits

    Submitting author: Jameel Barkat Lone, PhD (he/him/his) – Stanford University

    Rapid and Poster Presenter: Jameel Barkat Lone, PhD (he/him/his) – Stanford University

    Co-Author: Michelle To, Undergraduate student – Stanford University

    Co-Author: Laetitia Coassolo, PhD – Stanford University

    Co-Author: Zeyuan Zhang, PhD – Stanford University

    Co-Author: Quennie Nguyen, Postbac Student – Stanford University

    Co-Author: Saranya Reghupaty, PhD – Stanford University

    Co-Author: Khoa Trinh, Undergraduate Student – Stanford University

    Senior Author/Primary Investigator: Katrin Svensson, Associate Professor – Stanford University

  • 2:00 PM - 2:15 PM CT
    Tirzepatide Stimulates Brown Adipose Tissue Activity Independent of Weight Loss in Women with Obesity: TABFAT Trial

    Submitting author: Rok Herman, Medical Doctor (he/him/his) – University Medical Center Ljubljana

    Oral Abstract Presenter: Rok Herman, Medical Doctor (he/him/his) – University Medical Center Ljubljana

    Co-Author: Mojca Jensterle, Medical Doctor (she/her/hers) – University Medical Centre Ljubljana, Slovenia

    Co-Author: Luka Lezaic, Medical Doctor (he/him/his) – University Medical Centre Ljubljana

    Co-Author: Simon Horvat, n/a (he/him/his) – Biotechnical Faculty, University of Ljubljana

    Senior Author/Primary Investigator: Andrej Janez, Medical Doctor (he/him/his) – University Medical Centre Ljubljana

  • 2:15 PM - 2:30 PM CT
    Predictors of the Magnitude of Weight-Loss with Tirzepatide: A Cohort Study of over 80,000 Adults

    Senior Author/Primary Investigator: Ashley K. Clift, MA, MBBS, DPhil – Voy

    Submitting author: Hans Johnson, MBChB Mres MSc – UNIVERSITY OF BRISTOL

    Oral Abstract Presenter: Hans Johnson, MBChB Mres MSc – UNIVERSITY OF BRISTOL

    Senior Author/Primary Investigator: Hans Johnson, MBChB Mres MSc – UNIVERSITY OF BRISTOL

    Co-Author: Daniel Reisel, MBBS, DPhil – Voy

    Co-Author: David Huang, BSc, MBBS – Voy

    Senior Author/Primary Investigator: Ben Reis, PhD – Boston Children’s Hospital

  • 2:30 PM - 2:45 PM CT
    Novel Penetration Enhancers Enable Non-Invasive Sublingual and Transdermal Delivery of GLP-1 Receptor Agonists: Preclinical Evidence from Stearic Acid-Conjugated Protamine and Protamine Dimer Systems

    Co-Author: Edward J. Mills, PhD – McMaster University

    Co-Author: Kristian Thorlund, PhD – Redwood AI

    Submitting author: James Forrest, PhD – University of British Columbia

    Senior Author/Primary Investigator: Glenn Sammis, PhD – University of British Columbia

    Oral Abstract Presenter: Brodie Thomson

  • 2:45 PM - 3:00 PM CT
    Dual MC3R/MC4R Activation Drives Weight Loss, Limits Rebound, and Preserves Lean Mass in Obese Nonhuman Primates

    Submitting author: Jillian L. Seiler, PhD (she/her/hers) – Endevica Bio

    Oral Abstract Presenter: Jillian L. Seiler, PhD (she/her/hers) – Endevica Bio

    Co-Author: Emma-Xiaoyu Zhang

    Co-Author: Anna Impastato, PhD (she/her/hers) – Endevica Bio

    Co-Author: Kade Kelley, n/a – Endevica Bio

    Co-Author: Thomas Bennett, n/a (he/him/his) – Endevica Bio

    Co-Author: Bradley Studnitzer, PhD – Endevica Bio

    Co-Author: Claudia Prindle, PhD – Endevica Bio

    Co-Author: Benjamin Rajewski, PhD – Endevica Bio

    Co-Author: Barry A. Badeau, PhD – Endevica Bio

    Co-Author: Jordan Delev, BS – Endevica Bio

    Co-Author: Russell Potterfield, n/a – Endevica Bio

    Senior Author/Primary Investigator: Daniel L. Marks, MD, PhD (he/him/his) – Endevica Bio, Inc.

  • 3:00 PM - 3:15 PM CT
    Enhancing Fat Loss in Obese Mice through GLP1 Agonism and KHK Inhibition

    Submitting author: Jonathan Gao, BA (he/him/his) – NEW YORK UNIVERSITY MEDICAL CENTER

    Oral Abstract Presenter: Jonathan Gao, BA (he/him/his) – NEW YORK UNIVERSITY MEDICAL CENTER

    Co-Author: Jonathan Gao, BA (he/him/his) – NEW YORK UNIVERSITY MEDICAL CENTER

    Senior Author/Primary Investigator: Carolina Echeverria-Andrade, PhD (she/her/hers) – NEW YORK UNIVERSITY MEDICAL CENTER

    Co-Author: Carolina Echeverria-Andrade, PhD (she/her/hers) – NEW YORK UNIVERSITY MEDICAL CENTER

    Senior Author/Primary Investigator: Mujmmail Ahmed, BA (he/him/his) – University of California, Berkeley

    Co-Author: Mujmmail Ahmed, BA (he/him/his) – University of California, Berkeley

    Co-Author: Lucas Kniess Debarba, PhD (he/him/his) – NEW YORK UNIVERSITY MEDICAL CENTER

    Co-Author: Isaac Nathoo, BS (he/him/his) – NEW YORK UNIVERSITY MEDICAL CENTER

    Co-Author: Jeshua Kim, BA (she/her/hers) – NEW YORK UNIVERSITY MEDICAL CENTER

    Co-Author: Philip Moon, BA (he/him/his) – NEW YORK UNIVERSITY MEDICAL CENTER

    Co-Author: Sarah Stewart, BS (she/her/hers) – NEW YORK UNIVERSITY MEDICAL CENTER

    Co-Author: Odinakhon Shamieva, BA (she/her/hers) – NEW YORK UNIVERSITY MEDICAL CENTER

    Co-Author: Anthony Escamilla, n/a (he/him/his) – NEW YORK UNIVERSITY MEDICAL CENTER

    Senior Author/Primary Investigator: Marcus DaSilva Goncalves, MD, PhD (he/him/his) – NEW YORK UNIVERSITY MEDICAL CENTER

    Co-Author: Marcus DaSilva Goncalves, MD, PhD (he/him/his) – NEW YORK UNIVERSITY MEDICAL CENTER