Associate Professor of Pediatrics Columbia University Medical Center New York, NY, United States
Disclosure(s):
Vidhu Thaker, MD: No financial relationships to disclose
Maternal obesity and metabolic disease create a nutrient, hormonal, and inflammatory environment that shapes fetal development with lifelong consequences for metabolic regulation. This session will explore how these maternal influences alter offspring physiology. Talks will span epigenetic modifications, metabolomic and proteomic signaling.
Learning Objectives:
Understand how maternal metabolic status can leave durable marks on the offspring�s genome through DNA methylation, histone modifications, and non-coding RNAs.
Understand how advanced metabolomic and proteomic profiling reveals how maternal obesity alters nutrients, inflammatory signaling, placental transport and fetal growth
Understand how developing hypothalamus and reward-related brain circuits are highly sensitive to maternal nutrient and hormonal signals.
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