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J Carl Pallais, MD,MPH

Doctor
Brigham and Women's Hospital
Cambridge, MA, United States

Dr. J. Carl Pallais, MD, MPH completed college and medical school at Johns Hopkins University, followed by a year at Brigham and Women’s Hospital as a Howard Hughes Fellow. He earned an MPH at the Harvard School of Public Health and then completed internal medicine residency, chief residency, and fellowship training in endocrinology at Massachusetts General Hospital. He remained at MGH for more than a decade, where he directed the Endocrine Selective and received multiple teaching awards. He was subsequently recruited to Brigham and Women’s Hospital to serve as Master Clinician in Endocrinology and Associate Program Director for the Internal Medicine Residency Program. In this role, he maintains a busy referral practice in metabolic bone and mineral disorders while teaching and mentoring residents and fellows, and has received multiple awards for clinical excellence and medical education, including the Morse Family Distinguished Chair in Medical Education.
Dr. Pallais’s scholarly work focuses on metabolic bone and mineral disorders, with particular expertise in parathyroid disease and hypophosphatasia. His early work examined acquired and congenital disorders of calcium homeostasis and contributed to international clinical guidelines for hypoparathyroidism. Building on an interest in human genetics and participation in the Undiagnosed Diseases Network, he developed a clinical and research focus on hypophosphatasia, assembling a large and well-phenotyped cohort of patients with low alkaline phosphatase and skeletal disease. As Co-Director of the Center for Endocrine Genetics, he expanded access to genetic evaluation through coordinated virtual visits involving patients, family members, and genetic counselors. He currently serves as Site Principal Investigator for the Global Hypophosphatasia Registry and collaborates with system-wide biobank efforts to study ALPL variants and associated phenotypes. This work has led to multiple UpToDate chapters and invited national presentations, supporting ongoing efforts to improve diagnosis and care for patients with rare skeletal disease.

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