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Christian L. Roth, MD

Professor
Seattle Children's Rsrch Institute
Seattle, WA, United States

Christian Roth, MD, is a Pediatric Endocrinologist and Professor at Seattle Children's Research Institute, University of Washington, Dept. of Pediatrics, Seattle, WA. His recent publications focus on topics such as hyperphagia, hypothalamic obesity, and treatments involving GLP-1 analogs, phentermine/topiramate, and MC4R agonists. Dr. Roth is actively involved in clinical trials, serving as a principal investigator for studies related to obesity in youth and rare genetic disorders. In one of his studies he investigates how brain reward regions respond to food stimuli in children with obesity using functional MRI, both before and after behavioral interventions, with or without GLP-1 receptor agonist treatment
In preclinical research his lab uses rodent models to evaluate new anti-obesity agents, including multi-agonist peptides that target appetite and metabolism. Recent NIH-funded projects focus on compounds like GEP44 and KCEM1, examining how multi-receptor targeting affects energy balance and glucose regulation. Overall, the research integrates neuroimaging, clinical trials, peptide design, and drug development to advance safe and effective treatments for obesity.

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