SY22 - Maternal Adverse Metabolic Health and Offspring Developmental Programming: From Molecular Imprints to Weight

Symposium Chair(s)

• 

  Stephen Stone, MD (he/him/his)

  Assistant Professor
  Pediatrics
  Washington University School of Medicine
  Saint Louis, Missouri, United States

  Disclosure(s): No financial relationships to disclose
• 

  Maria Mericq, MD (she/her/hers)

  Full Professor
  Institute of Maternal and Child Research University of Chile
  Santiago, CHILE

  Disclosure(s): No financial relationships to disclose

Maternal obesity and metabolic disease create a nutrient, hormonal, and inflammatory environment that shapes fetal development with lifelong consequences for metabolic regulation. This session will explore how these maternal influences alter offspring physiology. Talks will span epigenetic modifications, metabolomic and proteomic signaling.

Presentations:

• 10:30 AM - 11:00 AM CT

  Molecular Memory: Epigenetic Rewiring of Offspring Following Adverse Maternal Metabolic Exposures
  

  Symposium Speaker: Jami Josefson, MD – Ann & Robert H Lurie Children's Hospital of Chicago
• 11:00 AM - 11:30 AM CT

  Lactation as a Window of Opportunity: How Diet and Exercise Alter Breast Milk Composition to Improve Offspring Metabolic Health
  

  Symposium Speaker: Michael Rudolph, PhD – OKLAHOMA UNIVERSITY HEALTH SCIENCE CENTER
• 11:30 AM - 12:00 PM CT

  Molecular Messengers: Metabolite and Transcriptomic Signatures of Maternal–fetal Crosstalk and Their Modulation by Bariatric Surgery
  

  Symposium Speaker: Vidhu Thaker, MD – Columbia University Medical Center